KAPA HyperCap Heredity Panel

Combining more than a decade of probe design experience with a high-fidelity probe manufacturing process, the KAPA HyperCap Heredity Panel enables comprehensive, in-depth access to hereditary disease genomic content. This compact panel for hybridization-based target enrichment offers greater sequencing efficiency, high on-target rates, and low PCR duplication rates. Order this 10 Mb hybrid capture panel today and start investigating heredity disease tomorrow.

Enrich for 3332 genes strongly associated with hereditary genetic diseases and oncology, including ClinVar pathogenic and likely pathogenic variants
Maximize sequencing efficiency with >98% target coverage at 30X with (10 M high-quality clusters)
Streamline targeted sequencing with the HyperCap Workflow v3, driven by KAPA HyperPrep or KAPA HyperPlus Library Prep Kits

Enrich for 3332 genes strongly associated with hereditary genetic diseases and oncology

Enrich for more than 85% of ClinVar pathogenic and likely pathogenic content at >30X by targeting 3332 carefully selected genes with a sequencing-efficient 10 Mb capture panel
Achieve a high percentage of bases covered at ≥30X for disease-associated genes from key genomic databases

Figure 1. Percent of bases in key genomic databases covered at ≥30X using the KAPA HyperCap Heredity Panel.

Target-enriched libraries were created following the standard KAPA HyperCap Workflow v3 with the KAPA HyperPrep Kit, using 100 ng of gDNA as input (96 library replicates; NA12878 DNA) and 12-plex pre-capture multiplexing for hybrid capture. Final libraries were sequenced on a NovaSeq™ 6000 system (2 x 100 bp) and downsampled to 10 M high-quality filtered clusters prior to analysis.

Project: KAPA HyperCap Fixed Panels, Pleasanton, CA 2021

Maximize sequencing efficiency with >98% target coverage at 30X with 10 M high-quality clusters

Enrich for more than 85% of ClinVar pathogenic and likely pathogenic content at >30X by targeting 3332 carefully selected genes with a sequencing-efficient 10 Mb capture panel
Achieve a high percentage of bases covered at ≥30X for disease-associated genes from key genomic databases

Figure 2. Key sequencing metrics generated with the KAPA HyperCap Heredity Panel.

Target-enriched libraries were created following the standard KAPA HyperCap Workflow v3 with the KAPA HyperPlus Kit, using 100 ng of gDNA as input (duplicate samples using gDNA from 16 Coriell cell lines) and 8-plex pre-capture multiplexing. Final libraries were sequenced on a NovaSeq™ 6000 system (2 x 100 bp) and downsampled to 10 M high-quality filtered clusters prior to analysis.

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Streamline target enrichment with the KAPA HyperCap Workflow v3

KAPA HyperCap Workflow v3 delivers complex libraries by combining the high conversion rate of KAPA HyperPrep or KAPA HyperPlus Kits with KAPA Target Enrichment, creating a streamlined, single-vendor supported workflow.

Explore KAPA Target Enrichment Probes: Better by Design

KAPA Target Enrichment Probes are manufactured with KAPA HiFi DNA Polymerase and demonstrate extremely high sequence fidelity, high on-target rates, and high accuracy and reproducibility.

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KAPA Code	Roche Cat. No	Description	Kit Size	How to buy
09462473001	09462473001	KAPA HyperCap Heredity Panel	12 rxn	Login for pricing
09462481001	09462481001	KAPA HyperCap Heredity Panel	24 rxn	Login for pricing
09462490001	09462490001	KAPA HyperCap Heredity Panel	48 rxn	Login for pricing
09462503001	09462503001	KAPA HyperCap Heredity Panel	96 rxn	Login for pricing
09462511001	09462511001	KAPA HyperCap Heredity Panel	192 rxn	Login for pricing