AVENIO Edge Liquid Handler

A differentiated liquid handler for automated NGS library prep

Simplify your NGS library prep with the AVENIO Edge System, a fully-automated IVD liquid handler for an end-to-end library preparation, target enrichment, quantification, normalization and pooling.

As little as 20 minutes of setup time
On-deck thermocycling and quantification
Ready-to-load barcoded reagent cartridges
Intuitive software and a glove-compatible touchscreen
No prior automation or NGS experience required

For more information, contact us.

AVENIO Edge System Use Cases

NGS library prep workflows are labor-intensive and time-consuming—especially if they include target enrichment (with oncology panels, for example). As a result, many genomics laboratories now rely on automated library preparation to streamline processes, reduce user-to-user variability, and improve reproducibility.

However, many of the automated liquid handlers on the market are cumbersome to program, set up, and run. Now, with the AVENIO Edge Liquid Handling System, labs that have no prior experience with NGS or automation can easily run complex library prep workflows—freeing up hours of time for other projects and reducing errors that can occur with manual methods.

Customer Testimonials

Queen's University Belfast shares how AVENIO Edge System got their ACTIONED Project on track.

Reliable and Simple to Use

"Using the Avenio Edge System we can free up team members to work in different parts of the project, or even take [on] new projects that bring additional value. The AVENIO Edge System has played a vital role in making sure that we can keep our TAT in check." Prof. David Gonzalez de Castro, PhD FRCPath

ctDNA Samples Analyzed Reliably

"The amount of the ctDNA that we have for each sample is very small. We therefore have only one opportunity to run the ctDNA on a library prep. With the AVENIO Edge we have the confidence and reliability that we can run ctDNA samples and [know] it will work." Peter Stewart, PhD

Download the Case Study from Queen's University Belfast

Short Intro to AVENIO Edge Liquid Handler for NGS Library Prep and Target Enrichment

Watch this ~2 min video to learn about the capabilities and specifications of the AVENIO Edge Liquid Handler for NGS library prep and target enrichment. The AVENIO Edge provides an end-to-end library prep workflow, including cleanup steps, quantification, normalization, and pooling.

Comparing the AVENIO Edge System vs. other traditional liquid handlers

Watch this video to learn how the AVENIO Edge IVD Liquid Handling System helps make it easier for molecular pathology labs to prepare next-generation sequencing (NGS) libraries for applications such as cancer research, exome sequencing, and beyond.

Pioneering the Evolution of Human Genetics Research

Watch Dr. Christien Betz describe how his lab uses KAPA HyperExome V2 and the AVENIO Edge Liquid Handling System to solve their whole-exome sequencing bottlenecks. Dr. Betz gave this presentation at the 2024 European Society of Human Genetics (ESHG) conference.

AVENIO Edge System Application Menu

View Full Table

Here is a growing menu of workflows currently available on the system:

Workflow	Maximum samples (Per Run)	Estimated setup time (minutes)
AVENIO Edge HyperPrep or AVENIO HyperPlus DNA library preparation*	48	20
AVENIO Edge Target Enrichment with KAPA HyperExome or custom panels**	48	20
AVENIO Edge HyperCap DNA library preparation and target enrichment*	24	20
Input DNA quantification, normalization and buffer exchange	96	15
Post-capture pooling and quantification	48	15
*These workflows use UDI primers and universal UMI or non-UMI adapters. **The input is indexed DNA or cDNA libraries

Prepare NGS libraries with no NGS or automation expertise

True walk-away NGS sample prep automation

AVENIO Edge System Deck Layout

Tip waste station
Thermal cycler
Heater/Shaker
Magnetic separation station
Plate and lid waste station
Tip park
Sample input station
Sample output station

9. Cooling unit

10. Tube racks

11. Piercing tool

12. Reagent mini racks

13. Reagent drawer

14. P1000, P200, P50 Filtered tips

15. Quantification plate station

16. Consumable drawer

17. Gripper fingers exchange station

18. Quantification module

19. 2D Barcode reader

20. Processing plates

21. Processing plate lids

Download brochure

Thinking of automating library prep on your existing liquid handler?

Roche’s NGS Automation Support Team, in collaboration with non-Roche liquid handling vendors, creates menus of automated methods for KAPA library prep reagents. Let’s talk about the next steps to get you up and running with automating your NGS library prep protocols. Visit support for non-Roche liquid handlers to learn more.

Support for automating KAPA reagents on non-Roche liquid handlers

Related Products

AVENIO Designer Software

Customize, convert and modify protocol for laboratory-defined workflows on the AVENIO Edge System.

...

AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

View Full Table

Roche Cat. No.	Description
09283234001	AVENIO Edge Instrument
09424962001	AVENIO Designer Software - Annual Subscription

View Full Table

Roche Cat. No.	Description	Kit Size
09200860001	AVENIO Edge DNA HyperPlus Kit	3 x 8 reactions
09200878001	AVENIO Edge DNA HyperPlus Kit	3 x 24 reactions
09200886001	AVENIO Edge DNA HyperPrep Kit	3 x 8 reactions
09200894001	AVENIO Edge DNA HyperPrep Kit	3 x 24 reactions
09200908001	AVENIO Edge Target Enrichment, A	3 x 8 reactions
09200916001	AVENIO Edge Target Enrichment, A	3 x 24 reactions
09200924001	AVENIO Edge Target Enrichment, B	3 sample runs
09200959001	AVENIO Edge UDI Primer Mixes Plate	96 wells of primer mixes
09200967001	AVENIO Edge HyperPure Beads	3 sample runs
09200975001	AVENIO Edge HyperPlex UMI Adapter	3 x 8 reactions
09200983001	AVENIO Edge HyperPlex UMI Adapter	3 x 24 reactions
09200991001	AVENIO Edge HyperPlex Adapters	3 x 8 reactions
09201009001	AVENIO Edge HyperPlex Adapters	3 x 24 reactions
09200851001	AVENIO Edge Quantification Kit	3 sample runs
09314512001	AVENIO Edge Solution A Kit	3 sample runs
09496386001	AVENIO Edge HyperPrep with UMI, 8 reactions Library Prep and Target Enrichement	3 x 8 reactions, 3 complete KAPA HyperCap runs
09496394001	AVENIO Edge HyperPrep without UMI, 8 reaction Library Prep and Target Enrichement	3 x 8 reactions, 3 complete KAPA HyperCap runs
09496408001	AVENIO Edge HyperPlus with UMI, 8 reaction Library Prep and Target Enrichement	3 x 8 reactions, 3 complete KAPA HyperCap runs
09496416001	AVENIO Edge HyperPlus without UMI, 8 reaction Library Prep and Target Enrichement	3 x 8 reactions, 3 complete KAPA HyperCap runs
09496424001	AVENIO Edge HyperPrep with UMI, 24 reactions Library Prep and Target Enrichement	3 x 24 reactions, 3 complete KAPA HyperCap runs
09496432001	AVENIO Edge HyperPrep without UMI 24 reactions Library Prep and Target Enrichement	3 x 24 reactions, 3 complete KAPA HyperCap runs
09496459001	AVENIO Edge HyperPlus with UMI, 24 reactions Library Prep and Target Enrichement	3 x 24 reactions, 3 complete KAPA HyperCap runs
09496467001	AVENIO Edge HyperPlus without UMI 24 reactions Library Prep and Target Enrichement	3 x 24 reactions, 3 complete KAPA HyperCap runs

View Full Table

Roche Cat. No.	Description	Package Size
09056351001	AVENIO Edge Tip Park	16 tip parks
08994609001	AVENIO Edge Processing Plate	50 plates
09030956001	AVENIO Edge Quantification Plate	50 plates
09031022001	AVENIO Edge Processing Plate Lid	50 lids
09031049001	AVENIO Edge Liquid Waste Plate	60 plates
09164081001	AVENIO Edge Tube, Panel 1	100 tubes
09164090001	AVENIO Edge Tube, Panel 2	100 tubes
09164103001	AVENIO Edge Tube, Panel 3	100 tubes
09164111001	AVENIO Edge Tube, Panel 4	100 tubes
09313630001	AVENIO Edge Pooling Tube	100 tubes
09336320001	AVENIO Edge Pipette Tip, 50 uL	24 boxes of 96 tips (total of 2304 tips)
09336346001	AVENIO Edge Pipette Tip, 200 uL	24 boxes of 96 tips (total of 2304 tips)
09336354001	AVENIO Edge Pipette Tip, 1000 uL	24 boxes of 96 tips (total of 2304 tips)

To place an order or ask a question

AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

Sarah is a lab technician who is responsible for performing many complex projects that require her full attention, including NGS library prep– not one of her favorite tasks. Sarah would love to automate her NGS workflows, but she just doesn’t have time to learn a complicated new system and optimize the workflows.

Nate is a lab manager who orchestrates the day-to-day activities in the lab, prioritizes projects, and oversees general lab operations. Although he manages the laboratory staff, including Sarah, he sometimes joins them at the bench -- especially when project deadlines are looming. Nate is also responsible for evaluating new technologies to determine if they are a good fit for his lab, as well as ensuring that existing instrumentation is maintained.

Kevin is an in-house automation engineer who has many years of robotics experience. He supports all the labs in his organization that operate automated liquid handlers, including Nate’s. An important part of his job is to work with both the automation vendors and the lab operators to implement and optimize new automated solutions. Kevin is an expert in what he does, but unfortunately he is the only automation specialist in the organization and there are many complex projects that require the support of an automation expert.

AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

For more information about the AVENIO Edge System please complete this form:

AVENIO Edge reagents and workflows are for Research Use Only. They are not intended for diagnostic applications.

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