For Research Use Only. Not for use in diagnostic procedures.
The KAPA HyperCap Heredity Panel is a 10 Mb capture target panel covering 3332 genes strongly associated with hereditary disease research, plus the ClinVar pathogenic and likely pathogenic variants content. It provides an optimal balance between relevant content carefully selected by the Roche Sequencing Scientists and sequencing efficiency driven from exceptional uniformity and very low duplication rates. It is readily available from stock and offers consistent quality by NGS probes QC of every lot. Sequencing data generated with the KAPA HyperCap Heredity Panel can be analyzed with Roche's cloud-based secondary analysis solution - the NAVIFY® Mutation Caller - for accurate detection of variants.
Figure 1. Key sequencing metrics with the KAPA HyperCap Heredity Panel. Eight-plex pre-capture multiplexing with the standard KAPA HyperCap Workflow v3 including the KAPA HyperPlus Kit from 100 ng gDNA (16 coriell cell lines in duplicate). Final libraries were sequenced on a NovaSeq™ 6000 system and downsampled to 10 M HQ filtered clusters (2 x 100 bp) prior to analysis.
Figure 2. Percent bases covered at 30x and above in key genomic databases using the KAPA HyperCap Heredity Panel. Twelve-plex precapture multiplexing with the standard KAPA HyperCap Workflow v3 and the KAPA HyperPrep Kit from 100 ng gDNA (96 replicates, NA12878). Final libraries were sequenced on a NovaSeq™ 6000 system and downsampled to 10 M high-quality filtered clusters (2 x 100 bp) prior to analysis.
|Cat Number||Description||Reaction pack size|
|09462473001||KAPA Heredity panel 12 rxn||12
|09462481001||KAPA Heredity panel 24 rxn||24|
|09462490001||KAPA Heredity panel 48 rxn||48
|09462503001||KAPA Heredity panel 96 rxn||96
|09462511001||KAPA Heredity panel 192 rxn||192|