Hybridization-Based Target Enrichment

Targeted sequencing enables researchers to enrich specific genes, exons and/or other genomic regions to allow sequencing reads to be dedicated to only the regions that are of interest, which results in time and cost savings.¹ To enrich specific target regions for next-generation sequencing (NGS) and bioinformatic analysis, hybridization or capture-based target enrichment is a method frequently used. This technique can be applied to single nucleotide polymorphism (SNP) detection, insertion/deletion (indel) detection, copy number variation (CNV) detection and structural variation detection.

Now available is Roche’s new KAPA HyperCap Target Enrichment Portfolio - KAPA HyperExome, KAPA HyperChoice and KAPA HyperExplore probes. Our industry-leading selection of probes will now offer higher performance, higher probe fidelity and in-solution hybridization capture, as well as longer probes with fixed length.

• Better capture uniformity
• Lower duplicate rate
• Higher target coverage
• Customer design expertise