AVENIO Tumor Tissue Analysis Kits

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Overview

AVENIO Tumor Tissue Analysis Kits are a portfolio of NGS assays that provide in-house tumor profiling, comprehensive genomic profiling (CGP), and surveillance & monitoring for clinical research. Through an optimized, end-to-end workflow, the kits offer a versatile solution to evaluate DNA extracted from formalin-fixed paraffin-embedded (FFPE) tissue samples.

 

Key Advantages of AVENIO Tumor Tissue Analysis Kits

  • All four mutation classes (SNVs, indels, fusions and CNVs) in a single DNA workflow with exceptional sensitivity and specificity1
  • 99% success rate for FFPE tissue samples that pass input QC testing using the AVENIO QC kit included with AVENIO tumor tissue assays
  • A streamlined, end-to-end workflow from extraction to analysis and reporting in 5 days
  • An integrated solution that includes reagents, intuitive analysis and reporting to facilitate in-house adoption of high-performance NGS oncology research

 

Benefits of AVENIO Tumor Tissue Targeted, Expanded and Surveillance Kits:

  • Matched tissue and ctDNA panels (same genes, gene regions and hybrid-capture workflow) to facilitate concordance analysis
  • Flexibility to switch between tissue and plasma to support a variety of research applications

 

Benefits of AVENIO Tumor Tissue CGP Kit

  • Designed to match the 324 gene FoundationOne® CDx panel content
  • Detects genomic signatures: TMB, MSI and LOH
infographic depicting the end to end workflow for the AVENIO tumor tissue analysis kits

Tumor tissue analysis kits

  1. Data on file.
  2. National Comprehensive Cancer Network.  October 15, 2016.
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AVENIO Tumor Tissue Targeted Kit

A 17 gene (81kb) pan-cancer assay that contains guideline-aligned biomarkers, including those identified by the U.S. National Comprehensive Cancer Network (NCCN).

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AVENIO Tumor Tissue Expanded Kit

A 77 gene (192kb) pan-cancer assay that contains 17 genes in the NCCN and other guidelines, plus 60 emerging biomarkers investigated in clinical trials.

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AVENIO Tumor Tissue Surveillance Kit

A 197 gene (198kb) assay, containing 17 NCCN guideline-aligned genes, plus 471 frequently mutated disease-associated regions across 197 genes; optimized for longitudinal monitoring of tumor burden in lung and colorectal cancer.

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AVENIO Tumor Tissue CGP Kit

Designed to match the content of the 324 gene FoundationOne® CDx panel, the assay detects four classes of genomic alterations as well as genomic signatures: TMB, MSI, LOH.

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