AVENIO ctDNA Analysis Kits

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Overview

AVENIO ctDNA Analysis Kits are a portfolio of three NGS liquid biopsy assays for oncology research. Using a streamlined workflow to evaluate ctDNA extracted from plasma, these assays provide an end-to-end solution for tumor profiling, longitudinal monitoring of tumor burden, and minimal residual disease (MRD) detection.

 

Key Advantages of AVENIO ctDNA Analysis Kits

  • Matched ctDNA and tissue panels (same genes, gene regions and hybrid-capture workflow) to facilitate concordance analysis
  • Includes genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines1
  • All four mutation classes (SNVs, indels, fusions and CNVs) in a single assay
  • Exceptional analytical performance supported by integrated digital error suppression (iDES) strategies combining molecular barcodes with in silico error suppression techniques2,3
  • Includes reagents for DNA extraction, library preparation and target enrichment, as well as bioinformatics and software required to analyze sequencing data and generate reports
  • Streamlined, end-to-end workflow from extraction to analysis and reporting in five days
infographic depicting the end to end workflow for the AVENIO ctDNA analysis kits

ctDNA analysis kits

  1. National Comprehensive Cancer Network.  October 15, 2016.
  2. Newman AM, Lovejoy AF, Klass DM, et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nature Biotechnology. 2016;34(5):547–555. doi:10.1038/nbt.3520.
  3. Data on file.
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AVENIO ctDNA Targeted Kit for NGS Liquid Biopsy

A 17 gene (81kb) pan-cancer assay containing genes in NCCN guidelines and optimized for lung cancer and colorectal cancer research.

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AVENIO ctDNA Expanded Kit for NGS Liquid Biopsy

A 77 gene (192kb) pan-cancer assay containing genes in the NCCN guidelines and emerging biomarkers, and optimized for lung cancer and colorectal cancer applications.

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AVENIO ctDNA Surveillance Kit for NGS Liquid Biopsy

A 197 gene (198kb) assay, containing 17 NCCN guideline-aligned genes, plus 471 frequently mutated disease-associated regions across 197 genes; optimized for longitudinal monitoring of tumor burden in lung and colorectal cancer.

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