AVENIO Edge System

AVENIO Edge System
Walk away from manual pipetting

Part of the Roche NGS Automation solution, the AVENIO Edge System* simplifies the inherent complexities of NGS workflows by automating key steps thereby optimizing lab resources, providing the freedom to walk away with confidence. 
 

The AVENIO Edge System is an all-in-one, pre-analytical platform that minimizes manual touchpoints, includes ready-to-load reagents, validated research protocols, on-board QC capabilities and intuitive software to manage your NGS sample workflows like never before.

Related information

Resources

Customer testimonial

Queen's University Belfast shares how AVENIO Edge System got their ACTIONED Project on track.

Queen's University Belfast summary video

This 2:22 video gives a brief overview of how the AVENIO Edge System brought a major project back online.

Queen's University Belfast extended video

In 7 minutes, learn how Queen's University Belfast used the AVENIO Edge System to clear a backlog of samples in record time for a mission critical project.

A tale of two labs

Watch this 4:30 video to see how labs can reconceptualize the work week with the AVENIO Edge through:

  • Roche's centralized solution to the NGS sample preparation automation challenge
  • Minimal interaction = On-deck thermal cycling, quantification and pooling
  • Pre-made, plug-and-play, barcoded reagents (no pipetting)* - powered by KAPA
  • 20 minutes to "set-it-and-forget-it"
  • Up to 36 hours unattended run time (library preparation and target enrichment in one touch)
NGS sample prep - automated with the AVENIO Edge System vs manual
AVENIO Edge workflow
AVENIO Edge System features and benefits

Components and run setup

Pierre-Luc Janvier, Senior Manager System development walks through the features and benefits of the AVENIO Edge System. (7:34)

AVENIO Edge System deck layout

AVENIO Edge system configuration
  1. Tip waste station
  2. Thermal cycler
  3. Heater/Shaker
  4. Magnetic separation station
  5. Plate and lid waste station
  6. Tip park
  7. Sample input station
  8. Sample output station

9.  Cooling unit

10. Tube racks

11. Piercing tool

12. Reagent mini racks

13. Reagent drawer

14.  P1000, P200, P50 Filtered tips

15. Quantification plate station

16. Consumable drawer

17. Gripper fingers exchange station

18. Quantification module

19. 2D Barcode reader

20. Processing plates

21. Processing plate lids

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AVENIO Software

Customize, convert and modify protocol for laboratory-defined workflows on the AVENIO Edge System.
...
    ...
    To place an order or ask a question
    Contact us

    *The AVENIO Edge System is a Class 1 US IVD and a Class A CE IVDR and is intended for downstream diagnostic applications. Reagents and kits mentioned are for Research Use Only. They are not intended for diagnostic procedures. The AVENIO Edge System can be used for Research Use Only (RUO) workflows.

    **User-defined protocols created using AVENIO Designer Software are for Research Use Only (RUO) workflows, not for use in diagnostic procedures.

    General

    • Configuration

      Floor model

    • Throughput per run

      1 - 48 samples for library prep and target enrichment

    • Runtime

      Up to 31 hrs (including 16 hrs hybridization time)

    • Setup time

      Approximately 15 mins prior to run

    • Inventory check

      Pre-run consumable list. Pre-run check for empty positions and incorrectly placed items

    • Quality control on deck

      Fluorescence-based quantifiction method

    • Barcodes

      2D imager scans for 2D and 1D barcodes

    • Regulatory label

      US-IVD, CE-IVD

    Kits and applications

    • Reagent design

      Pre-filled, barcoded, ready-to-use. Reagent kits are optimized for 3 runs.*

    • Sample type

      Extracted DNA samples

    • Workflow

      Library preparation + Hybridization-based target enrichment

    AVENIO Edge System Application Menu

    A growing application menu of user-defined workflows


    More validated Roche protocols to come in the future

    View Full Table
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    Workflow Maximum samples (Per Run) Estimated setup time (minutes)
    AVENIO Edge HyperPrep or AVENIO HyperPlus DNA library preparation** 48 20
    AVENIO Edge Target Enrichment with KAPA HyperExome or custom panels*** 48 20
    AVENIO Edge HyperCap DNA library preparation and target enrichment** 24 20
    Input control - input sample quantification, normalization, and buffer exchange 96 15
    Post-capture pooling and quantification – options for using external QC metrics 48 15

    Software and connectivity

    • Traceability

      21 CFR part 11 compliant (subsection B), audit trail, process monitoring, user guidance

    • Data export

      CSV, XML and PDF run exports. Sample input in .csv format

    • Interfaces

      2 external USB ports and 1 network port

    • Connectivity

      HL7 LIS connection, Roche remote service solution
    To place an order or ask a question
    Contact us

    * For Research Use Only. Not for use in diagnostic procedures.

    ** These workflows use UDI primers and universal UMI or non-UMI adapters.

    *** The input is indexed DNA or cDNA libraries

    The AVENIO Edge System is a Class 1 US IVD and a Class A CE IVDR and is intended for downstream diagnostic applications.

    Reagents and kits mentioned are for Research Use Only. They are not intended for diagnostic procedures.
    The AVENIO Edge System can be used for Research Use Only (RUO) workflows.

    View Full Table
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    Roche Cat. No.
    		 Description
    9283234001 AVENIO Edge Instrument
    9424962001 AVENIO Designer Software - Annual Subscription
    View Full Table
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    Roche Cat. No.
    		 Description
    		 Kit Size
    9200860001 AVENIO Edge DNA HyperPlus Kit 3 x 8 reactions
    9200878001 AVENIO Edge DNA HyperPlus Kit 3 x 24 reactions
    9200886001 AVENIO Edge DNA HyperPrep Kit 3 x 8 reactions
    9200894001 AVENIO Edge DNA HyperPrep Kit 3 x 24 reactions
    9200908001 AVENIO Edge Target Enrichment, A 3 x 8 reactions
    9200916001 AVENIO Edge Target Enrichment, A 3 x 24 reactions
    9200924001 AVENIO Edge Target Enrichment, B 3 sample runs
    9200959001 AVENIO Edge UDI Primer Mixes Plate 96 wells of primer mixes
    9200967001 AVENIO Edge HyperPure Beads 3 sample runs
    10244844001 AVENIO Edge UDI Adapter 15μM Plate 96 reactions
    9200975001 AVENIO Edge HyperPlex UMI Adapter 3 x 8 reactions
    9200983001 AVENIO Edge HyperPlex UMI Adapter 3 x 24 reactions
    9200991001 AVENIO Edge HyperPlex Adapters 3 x 8 reactions
    9201009001 AVENIO Edge HyperPlex Adapters 3 x 24 reactions
    9200851001 AVENIO Edge Quantification Kit 3 sample runs
    9314512001 AVENIO Edge Solution A Kit 3 sample runs
    9496386001 AVENIO Edge HyperPrep with UMI, 8 reactions Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    9496394001 AVENIO Edge HyperPrep without UMI, 8 reaction Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    9496408001 AVENIO Edge HyperPlus with UMI, 8 reaction Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    9496416001 AVENIO Edge HyperPlus without UMI, 8 reaction Library Prep and Target Enrichement 3 x 8 reactions, 3 complete KAPA HyperCap runs
    9496424001 AVENIO Edge HyperPrep with UMI, 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    9496432001 AVENIO Edge HyperPrep without UMI 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    9496459001 AVENIO Edge HyperPlus with UMI, 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    9496467001 AVENIO Edge HyperPlus without UMI 24 reactions Library Prep and Target Enrichement 3 x 24 reactions, 3 complete KAPA HyperCap runs
    View Full Table
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    Roche Cat. No.
    		 Description
    		 Package Size
    9056351001 AVENIO Edge Tip Park 16 tip parks
    8994609001 AVENIO Edge Processing Plate 50 plates
    9030956001 AVENIO Edge Quantification Plate 50 plates
    9031022001 AVENIO Edge Processing Plate Lid 50 lids
    9031049001 AVENIO Edge Liquid Waste Plate 60 plates
    9164081001 AVENIO Edge Tube, Panel 1 100 tubes
    9164090001 AVENIO Edge Tube, Panel 2 100 tubes
    9164103001 AVENIO Edge Tube, Panel 3 100 tubes
    9164111001 AVENIO Edge Tube, Panel 4 100 tubes
    9313630001 AVENIO Edge Pooling Tube 100 tubes
    9336320001 AVENIO Edge Pipette Tip, 50 uL 24 boxes of 96 tips (total of 2304 tips)
    9336346001 AVENIO Edge Pipette Tip, 200 uL 24 boxes of 96 tips (total of 2304 tips)
    9336354001 AVENIO Edge Pipette Tip, 1000 uL 24 boxes of 96 tips (total of 2304 tips)
    To place an order or ask a question
    Contact us

    The AVENIO Edge System is a Class 1 US IVD and a Class A CE IVDR and is intended for downstream diagnostic applications. Reagents and kits mentioned are for Research Use Only. They are not intended for diagnostic procedures. The AVENIO Edge System can be used for Research Use Only (RUO) workflows.