Research Area



The field of molecular oncology has witnessed tremendous progress in the past decade, thanks to advancements in technologies such as next generation sequencing (NGS) and liquid biopsy, a non-invasive sampling method that offers the potential for new applications in oncology research.

Roche Sequencing Solutions offers complete NGS ctDNA and tumor tissue assay kits and reagents for oncology research applications.



AVENIO NGS Oncology Assays*

AVENIO ctDNA Analysis Kits

AVENIO ctDNA Targeted Kit
Tumor profiling

AVENIO ctDNA Expanded Kit
Expanded tumor profiling

AVENIO ctDNA Surveillance Kit
Longitudinal tumor burden monitoring


AVENIO Tumor Tissue Analysis Kits

AVENIO Tumor Tissue Targeted Kit
Tumor profiling

AVENIO Tumor Tissue Expanded Kit
Expanded tumor profiling

AVENIO Tumor Tissue Surveillance Kit
Longitudinal tumor burden monitoring

AVENIO Tumor Tissue CGP Kit
Comprehensive Genomic Profilingᐩ

  • Portfolio of assays provide flexibility to match the right test to the right research goal. 
  • Tumor tissue and liquid biopsy assays with matching gene panels
  • Flexibility to match the right assay to the right research goal Includes genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines1 
  • All four mutation classes (SNVs, inDels, fusions and CNVs) in a single assay 
  • Exceptional analytical performance backed by robust data2,3 
  • End-to-end workflow from extraction to analysis and reporting in five days 
  • Detects genomic signatures: TMB, MSI and LOHᐩ


+ Only applicable to AVENIO Tumor Tissue CGP Kits
Workflow Step
Sample QC

Reliable quantification and quality assessment of low-input or FFPE samples to optimize library construction yields and workflows

Target Enrichment

KAPA HyperCap

KAPA HyperExome

KAPA HyperChoice (human designs)

KAPA HyperExplore (non-human designs)

KAPA HyperCap Oncology Panel

KAPA HyperCap Heredity Panel


  • Reduce sequencing costs and save time with superior capture uniformity
  • Demonstrated design expertise, 10+ years of experience
  • Reliably enrich challenging, previously inaccessible genomic regions


KAPA HyperPETE Choice / Explore (human designs)

KAPA HyperPETE Choice / Explore RNA (human designs)

KAPA HyperPETE Pan Cancer Panel

KAPA HyperPETE Hot Spot Panel

KAPA HyperPETE Hereditary Oncology Panel

KAPA HyperPETE Lung Cancer Fusion Panel

  • Save valuable time with an efficient, single-day, automatable workflow
  • Achieve superior performance and coverage uniformity
  • Uncover critical genomic information from a wide variety of sample types, including FFPET and cfDNA
  • Detect all major somatic variants in cfDNA, FFPE, and RNA samples, including SNVs, short indels, CNVs, MSI, and fusion transcripts (novel and known)
KAPA HyperCap Workflow v3 Streamline targeted sequencing with HyperCap workflow v3
Library Preparation

KAPA DNA Library Preparation Kits

KAPA Library Preparation Accessories

KAPA Adapters

KAPA Library Amplification Kits

KAPA Library Quantification Kits

Tailor your library preparation workflow to your needs with a portfolio of streamlined, versatile solutions that reliably preserve sample sequence complexity for improved sequencing outcomes




Sample Collection

AVENIO Millisect System
  • Maximize clinical utility of tissue samples by identifying mutations missed with manual dissection and reducing false negative rates3,4
  • Increase dissection efficiency and optimize results by capturing clinically relevant cells3
  • Improve lab workflow and minimize demands on staff by ensuring consistent sample capture through an automated, digitally assisted process
  1.  National Comprehensive Cancer Network. October 15, 2016.
  2.  Newman AM, Lovejoy AF, Klass DM, et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nature Biotechnology. 2016;34(5):547–555. 
  3. Geiersbach K, Ady N, Welker N, et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genetics. 2016;209(1-2):42- 49. 2.
  4. Gustafson H, Theiss N, Hnatyszyn JH. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integrative Cancer Science and Therapeutics. 2016;3(4):500-503.
  5. Data on file.


*Research Use Only. Not for use in diagnostic procedures.