Oncology

Overview

The field of molecular oncology has witnessed tremendous progress in the past decade, thanks to advancements in technologies such as next generation sequencing (NGS) and liquid biopsy, a non-invasive sampling method that offers the potential for new applications in oncology research.

Roche Sequencing Solutions offers NGS assay kits and reagents for oncology research applications.

Assays
Products Benefits

AVENIO Tumor Tissue and ctDNA Analysis Kits*

NGS Oncology assays

AVENIO ctDNA Targeted Kit
Tumor profiling

AVENIO ctDNA Expanded Kit
Expanded tumor profiling

AVENIO ctDNA Surveillance Kit
Longitudinal tumor burden monitoring

AVENIO Tumor Tissue Targeted Kit
Tumor profiling

AVENIO Tumor Tissue Expanded Kit
Expanded tumor profiling

AVENIO Tumor Tissue Surveillance Kit
Baseline for longitudinal monitoring of tumor burden

  • Tumor tissue and liquid biopsy assays with matching gene panels
  • Flexibility to match the right assay to the right research goal
  • Includes genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines1
  • All four mutation classes (SNVs, inDels, fusions and CNVs) in a single assay
  • Exceptional analytical performance backed by robust data2,3
  • End-to-end workflow from extraction to analysis and reporting in five days

 

Reagents Products Benefits
Sample QC Reagents*
KAPA hgDNA Quantification & QC Kits
  • Reliable quantification and quality assessment of low-input or FFPE samples to optimize library construction yields and workflows

 

Target Enrichment Reagents*

KAPA Custom Probes

HyperCap Workflow products

  • Shared Designs contains pre-designed NGS panels
  • Reduced sequencing costs
  • Customization to capture your regions of interest
  • Integrated, streamlined workflow solution
Library Preparation Reagents*

KAPA HyperPrep Kits

KAPA HyperPlus Kits

  • High-quality library construction from FFPE and challenging samples in less than 3 hours
  • Low bias enzymatic fragmentation for construction of high-quality libraries from microbes with extreme genomic GC content
Library Amplification Reagents*
KAPA Library Amplification Kit
  • Minimal amplification bias for improved sequencing coverage in WGS workflows that require library amplification
Library Quantification Reagents*
KAPA Library Quantification Kits
  • Accurate quantification of adapter-ligated molecules prior to sample pooling and cluster generation or template preparation for optimal sequencing results
Instruments Products Benefits

Automated Tissue Disection

 

AVENIO Millisect System
  • Maximize clinical utility of tissue samples by identifying mutations missed with manual dissection and reducing false negative rates3,4
  • Increase dissection efficiency and optimize results by capturing only clinically relevant cells3
  • Improve lab workflow and minimize demands on staff by ensuring consistent sample capture through an automated, digitally assisted process5

 

Software Products Benefits
Decision Support -- Clinical Reporting NAVIFY Mutation Profiler
  • Accurate and efficient interpretation of clinical significance of mutations
  • Richly curated and up-to-date knowledge base for thousands of variants, classified in accordance of clinical significance
  • Potential personalized treatment strategies outlined in a concise, professional oncologist report
  • Summarized currently approved or recommended treatments, as well as relevant clinical trials
  1.  National Comprehensive Cancer Network. October 15, 2016.
  2.  Newman AM, Lovejoy AF, Klass DM, et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nature Biotechnology. 2016;34(5):547–555. 
  3. Geiersbach K, Ady N, Welker N, et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genetics. 2016;209(1-2):42- 49. 2.
  4. Gustafson H, Theiss N, Hnatyszyn JH. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integrative Cancer Science and Therapeutics. 2016;3(4):500-503.
  5. Data on file.

*Research Use Only. Not for use in diagnostic procedures.