Overview

SeqCap® Epi Choice Probes enable targeting of selected human genomic regions from bisulfite-treated genomic DNA in a single workflow. The probes are customizable probe pools that can target both strands of bisulfite-treated human genomic DNA for targets up to 90Mb.

Benefits of SeqCap Epi Probes

Efficient discovery of differential methylation

  • Target up to 90Mb of genomic regions to obtain better depth of coverage and higher resolution of differential methylation compared to whole genome bisulfite sequencing

 

Optimized design and workflow to effectively conserve epigenome complexity

  • Obtain superior target enrichment performance with an advanced design algorithm coupled with over 2.1 million long oligonucleotide probes
  •  Observe methylation changes on both strands while preserving the ability to decipher between SNPs vs. methylation events, with an industry-leading sample input of just 1µg*

 

Maximized epigenetic discovery

  •  Reduce the amount of sequencing  needed to discover and validate methylation events potentially responsible for disease by focusing on your region of interest


Custom Designs

  • NimbleDesign, our free online tool, enables you to quickly and easily design custom SeqCap EZ Choice, SeqCap EZ Choice XL or HEAT-Seq® Choice Designs for human and non-human research applications. Learn more about the NimbleDesign software for custom target enrichment designs.

*Data on file.