Overview

The AVENIO Millisect System is an automated, high-performance tissue dissection system that enables precise and consistent recovery of formalin-fixed paraffin-embedded (FFPE) tissue areas of interest for molecular pathology. The system is optimized to fit easily into a variety of clinical workflow configurations, improves diagnostic testing results by reducing false negatives, and can help you efficiently extract more clinically relevant information from every sample.

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Processing challenging tumor samples via automated tissue dissection and extraction-free library prep.

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Benefits

  • Maximize clinical utilityof tissue samples by identifying mutations missed with manual dissection and reducing false negative rates1,2
  • Increase dissection efficiency and optimize results by capturing only clinically relevant cells1
  • Improve lab workflow and minimize demands on staff by ensuring consistent sample capture through an automated, digitally assisted process3

Product Highlights

Digital annotation

  • Allows definition of multiple Areas of Interest (AOIs) on a single slide, without limits on geometry
  • Digitally-assisted alignment to reference slide for up to 4 serial slides
  • Intuitive software interface to guide user annotations



Automated milling

  • Faster process with fewer steps and no pre-staining
  • Precise milling displaces tissue AOIs as small as 250 μm using a rotating action
  • Automated consumable loading, reagent filling and unloading

Gentle recovery

  • Hands-free process minimizes potential for contamination
  • Capillary action used to lift and recover AOIs after milling
  • No risk of burning or losing sample with gentle, non-laser optics



Comprehensive reporting

  • Electronic report file, including images, annotations and notes, exportable as a PDF
  • Pre-and post-dissection image capture
  • Barcode scanning for improved chain of custody

AVENIO Millisect System at The Ottawa Hospital

Dr. Bryan Lo at The Ottawa Hospital in Canada talks about the need to precisely isolate tumor content as tumor biopsies get smaller in the future. Learn how the AVENIO Millisect System can improve molecular diagnostics laboratory workflow.

Publications

  • Adey, N. et al. A mill based instrument and software system for dissecting slide-mounted tissue that provides digital guidance and documentation. BMC Clin Pathol. 2013; 13:29. doi:10.1186/1472-6890-13-29
  • Hudock, T., & Kaushal, D. A novel microdissection approach to recovering Mycobacterium tuberculosis specific transcripts from formal fixed paraffin embedded lung. J Vis Exp. 2014; 88:1-7. doi:10.3791/51693
  • Krizman, D., Adey, N., & Parry, R. Application of tissue mesodissection* to molecular cancer diagnostics. J Clin Pathol. 2015; 68: 166-169. doi:10.1136/jclinpath-2014-202723
  • Geiersbach, K. et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genet. 2016; 209:42-49. doi:10.1016/j.cancergen.2015.12.004 
  • Gustafson, H., Theiss, N., & Hnatyszyn, J.H. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integr Cancer Sci Therap. 2016; 3(4):500-503. doi:10.15761/ICST.1000197
  • Kader, T., et al. Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formal-fixed paraffin embedded tumor tissue. Genome Med. 2016; 8:21. doi:10.1186/s13073-016-0375-z

References

1. Geiersbach K et al. Cancer Genet. 2016;209(1-2):42-49. 2.

2. Gustafson Het al. Integr Cancer Sci Therap. 2016;3(4):500-503.

3. Data on file.