Overview

The AVENIO Millisect System is an automated, high-performance tissue dissection system that enables precise and consistent recovery of formalin-fixed paraffin-embedded (FFPE) tissue areas of interest for molecular pathology. The system is optimized to fit easily into a variety of clinical workflow configurations, improves diagnostic testing results by reducing false negatives, and can help you efficiently extract more clinically relevant information from every sample.

AVENIO Millisect System at The Ottawa Hospital

Dr. Bryan Lo at The Ottawa Hospital in Canada talks about the need to precisely isolate tumor content as tumor biopsies get smaller in the future. Learn how the AVENIO Millisect System can improve molecular diagnostics laboratory workflow.

Benefits

  • Optimize tumor yield and minimize contamination with precise tissue dissection1
  • Maximize actionable tumor information and reduce false negative results1,2
  • Improve laboratory workflow by ensuring sample acquisition is efficient, consistent3 and traceable.

Product Highlights

Digital annotation

  • Allows definition of multiple Areas of Interest (AOIs) on a single slide, without limits on geometry
  • Digitally-assisted alignment to reference slide for up to 4 serial slides
  • Intuitive software interface to guide user annotations



Automated milling

  • Faster process with fewer steps and no pre-staining
  • Precise milling displaces tissue AOIs as small as 250 μm using a rotating action
  • Automated consumable loading, filling and unloading

Gentle recovery

  • Hands-free process minimizes potential for contamination
  • Capillary action used to lift and recover AOIs after milling
  • No risk of burning or losing sample with gentle, non-laser dissection



Comprehensive reporting

  • Electronic report file, including images, annotations and notes, exportable as a PDF
  • Pre-and post-dissection image capture
  • Barcode scanning for improved traceability

Publications

  • Kader, T. et al. Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma. J Pathol. 2019 Jul;248(3):326-338. doi:10.1002/path.5262
  • Weberpals, JI. et al. Vulvar squamous cell carcinoma (VSCC) as two diseases: HPV status identifies distinct mutational profiles including oncogenic fibroblast growth factor receptor 3. Clin Cancer Res. 2017 Aug 1;23(15):4501-4510. doi:10.1158/1078-0432.CCR-16-3230
  • Kader, T., et al. Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue. Genome Med. 2016; 8:21. doi:10.1186/s13073-016-0375-z
  • Gustafson, H., Theiss, N., & Hnatyszyn, J.H. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integr Cancer Sci Therap. 2016; 3(4):500-503. doi:10.15761/ICST.1000197
  • Geiersbach, K. et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genet. 2016; 209:42-49. doi:10.1016/j.cancergen.2015.12.004
  • Krizman, D., Adey, N., & Parry, R. Application of tissue mesodissection to molecular cancer diagnostics. J Clin Pathol. 2015; 68: 166-169. doi:10.1136/jclinpath-2014-202723
  • Hudock, T., & Kaushal, D. A novel microdissection approach to recovering Mycobacterium tuberculosis specific transcripts from formalin-fixed paraffin embedded lung granulomas. J Vis Exp. 2014; 88:1-7. doi:10.3791/51693
  • Adey, N. et al. A mill based instrument and software system for dissecting slide-mounted tissue that provides digital guidance and documentation. BMC Clin Pathol. 2013; 13:29. doi:10.1186/1472-6890-13-29

References

1. Geiersbach K et al. Cancer Genet. 2016;209(1-2):42-49. 2.

2. Gustafson H et al. Integr Cancer Sci Therap. 2016;3(4):500-503.

3. Data on file.