The field of molecular oncology has witnessed tremendous progress in the past decade, thanks to advancements in technologies such as next generation sequencing (NGS) and liquid biopsy, a non-invasive sampling method that offers the potential for new applications in oncology research.

Roche Sequencing Solutions offers complete NGS ctDNA and tumor tissue assay kits and reagents for oncology research applications.




AVENIO family of NGS Oncology Assays*

A uniquely versatile solution for comprehensive tumor profiling, monitoring and concordance analysis.

AVENIO ctDNA Analysis Kits

AVENIO ctDNA Targeted Kit
Tumor profiling

AVENIO ctDNA Expanded Kit
Expanded tumor profiling

AVENIO ctDNA Surveillance Kit
Longitudinal tumor burden monitoring


AVENIO Tumor Tissue Analysis Kits

AVENIO Tumor Tissue Targeted Kit
Tumor profiling

AVENIO Tumor Tissue Expanded Kit
Expanded tumor profiling

AVENIO Tumor Tissue Surveillance Kit
Longitudinal tumor burden monitoring

  • Portfolio of assays provide flexibility to match the right test to the right research goal
  • Includes genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines1
  • All four mutation classes (SNVs, indels, fusions and CNVs) in a single assay
  • Exceptional analytical performance backed by robust data2,3
  • End-to-end workflow from extraction to analysis and reporting in five days


Reagents Products Benefits
Sample QC Reagents*
KAPA hgDNA Quantification & QC Kits
  • Reliable quantification and quality assessment of low-input or FFPE samples to optimize library construction yields and workflows
Target Enrichment Reagents*

KAPA HyperChoice (human designs)

KAPA HyperExplore (non-human designs)

KAPA HyperCap Workflow v3

  • Reduce sequencing costs and save time with superior capture uniformity
  • Demonstrated design expertise, 10+ years of experience
  • Reliably enrich challenging, previously inaccessible genomic regions
  • Streamline targeted sequencing with HyperCap workflow v3
Library Preparation Reagents*

KAPA HyperPrep Kits

KAPA HyperPlus Kits

KAPA HTP/LTP Library Preparation Kits

  • High-quality library construction from FFPE and challenging samples in less than 3 hours
  • Low bias enzymatic fragmentation for construction of high-quality libraries from microbes with extreme genomic GC content
Library Amplification Reagents*
KAPA Library Amplification Kit
  • Minimal amplification bias for improved sequencing coverage in WGS workflows that require library amplification
Library Quantification Reagents*
KAPA Library Quantification Kits
  • Accurate quantification of adapter-ligated molecules prior to sample pooling and cluster generation or template preparation for optimal sequencing results



Sample Collection


AVENIO Millisect System
  • Maximize clinical utility of tissue samples by identifying mutations missed with manual dissection and reducing false negative rates3,4
  • Increase dissection efficiency and optimize results by capturing clinically relevant cells3
  • Improve lab workflow and minimize demands on staff by ensuring consistent sample capture through an automated, digitally assisted process



  1.  National Comprehensive Cancer Network. October 15, 2016.
  2.  Newman AM, Lovejoy AF, Klass DM, et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nature Biotechnology. 2016;34(5):547–555. 
  3. Geiersbach K, Ady N, Welker N, et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genetics. 2016;209(1-2):42- 49. 2.
  4. Gustafson H, Theiss N, Hnatyszyn JH. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integrative Cancer Science and Therapeutics. 2016;3(4):500-503.
  5. Data on file.

*Research Use Only. Not for use in diagnostic procedures.