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Oncology

Overview

The field of molecular oncology has witnessed tremendous progress in the past decade, thanks to advancements in technologies such as next generation sequencing (NGS) and liquid biopsy, a non-invasive sampling method that offers the potential for new applications in oncology research.

Roche Sequencing Solutions offers complete NGS ctDNA assay kits and reagents for oncology research applications.

Assays

Product

 Benefits

AVENIO ctDNA Analysis Kits*

A portfolio of three NGS liquid biopsy assays

AVENIO ctDNA Targeted Kit
Tumor profiling

AVENIO ctDNA Expanded Kit
Expanded tumor profiling

AVENIO ctDNA Surveillance Kit
Longitudinal tumor burden monitoring
  • Flexibility to match the right assay optimized for the right research goal
  • Includes genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines1
  • All four mutation classes (SNVs, indels, fusions and CNVs) in a single assay
  • Exceptional analytical performance backed by robust data2,3
  • End-to-end workflow from extraction to analysis and reporting in five days

 
Reagents Products Benefits
Sample QC Reagents*
 KAPA hgDNA Quantification & QC Kits
  • Reliable quantification and quality assessment of low-input or FFPE samples to optimize library construction yields and workflows

 
Target Enrichment Reagents*

SeqCap® EZ Designs

SeqCap EZ Choice

SeqCap RNA System

SeqCap Epi System
  • Reduced sequencing costs
  • Customization to capture your regions of interest
Library Preparation Reagents*

KAPA HyperPrep Kits

KAPA HyperPlus Kits

KAPA HTP/LTP Library Preparation Kits
  • High-quality library construction from FFPE and challenging samples in less than 3 hours
  • Low bias enzymatic fragmentation for construction of high-quality libraries from microbes with extreme genomic GC content
Library Amplification Reagents*
 KAPA Library Amplification Kit
  • Minimal amplification bias for improved sequencing coverage in WGS workflows that require library amplification
Library Quantification Reagents*
 KAPA Library Quantification Kits
  • Accurate quantification of adapter-ligated molecules prior to sample pooling and cluster generation or template preparation for optimal sequencing results
Instruments

Product

 Benefits

Sample Collection

 

 AVENIO Millisect System
  • Maximize clinical utility of tissue samples by identifying mutations missed with manual dissection and reducing false negative rates3,4
  • Increase dissection efficiency and optimize results by capturing clinically relevant cells3
  • Improve lab workflow and minimize demands on staff by ensuring consistent sample capture through an automated, digitally assisted process

 

References

  1.  National Comprehensive Cancer Network. October 15, 2016.
  2.  Newman AM, Lovejoy AF, Klass DM, et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nature Biotechnology. 2016;34(5):547–555. 
  3. Geiersbach K, Ady N, Welker N, et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genetics. 2016;209(1-2):42- 49. 2.
  4. Gustafson H, Theiss N, Hnatyszyn JH. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integrative Cancer Science and Therapeutics. 2016;3(4):500-503.
  5. Data on file.

*Research Use Only. Not for use in diagnostic procedures. 

AVENIO, KAPA, SEQCAP and MILLISECT are trademarks of Roche. Other product names and trademarks are the property of their respective owners.