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AVENIO ctDNA Expanded Kit

Overview

The AVENIO ctDNA Expanded Kit is a next-generation sequencing (NGS) liquid biopsy assay with a 77 gene panel containing genes in U.S. National Comprehensive Cancer Network (NCCN) Guidelines1 and emerging cancer biomarkers. The Expanded Kit is a pan-cancer assay that’s specially optimized for lung cancer and colorectal cancer (CRC).

Features and Benefits of AVENIO ctDNA Expanded Kit

  • Contains genes in the U.S. National Comprehensive Cancer Network (NCCN) Guidelines1 and emerging cancer biomarkers
  • All four mutation classes (SNVs, indels, fusions and CNVs) in a single assay
  • Exceptional analytical performance supported by integrated digital error suppression (iDES) strategies combining molecular barcodes with in silico error suppression techniques2,3
  • Includes reagents, bioinformatics and software
  • Streamlined, end-to-end workflow from extraction to analysis and reporting in five days

Product Highlights

Accurate detection of all four classes of mutations with high sensitivity and specificity2,3

  • >99% sensitivity SNVs, indels and fusions and >96% CNVs
  • >99% positive predictive value (PPV) for indels, fusions and CNVs, and >98% PPV for SNVs

View performance data of the the AVENIO ctDNA Expanded Kit.

Profiling of a broad array of genes with a single assay kit

  • 77 assay targets in a single panel

View AVENIO ctDNA Expanded Kit assay targets.

A portfolio of NGS liquid biopsy assays  

The AVENIO ctDNA Expanded Kit is one of three assays in the AVENIO ctDNA assay portfolio. Learn more about the 17-gene AVENIO ctDNA Targeted Kit for guideline-driven tumor profiling or the 197-gene AVENIO ctDNA Surveillance Kit for longitudinal tumor burden monitoring.

References

1. National Comprehensive Cancer Network. October 15, 2016

2. Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nature Medicine. 2014;20(5):548–554 doi:10.1038/nm.3519

3. Data on file.

Research Use Only. Not for use in diagnostic procedures.
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