Roche at the AMP 2021 Digital Experience

November 15th - 19th, 2021

Roche at the AMP 2021 Digital Experience

Join Us at our Corporate Workshop

Performance of NGS-based profiling of TMB, MSI, and cancer alterations using the AVENIO Tumor Tissue CGP Kit across multiple laboratory sites


Time: 
1:30pm - 2:20pm (ET), 10:30am - 11:20am (PT)

Date: Friday, November 19th 2021
Location: Virtual, hosted on the AMP Virtual Experience Platform

Abstract: Comprehensive genomic profiling of FFPE tissues through NGS empowers the advancement of clinical research. Roche has developed a Research Use Only test, the AVENIO Tumor Tissue CGP Kit, which is designed to match Foundation Medicine’s 324 gene FoundationOne®CDx Panel content. This new kit provides laboratories with distributed reagents and a cloud-based analysis software, for an end-to-end in-house solution to profile 324 genes associated with solid tumors across multiple cancer types, including genomic loss of heterozygosity, microsatellite instability, and tumor mutation burden. Here, we report high reproducibility and performance across five laboratory sites using a characterized panel of FFPET samples.

Speaker: Jonathan Choi, Senior Manager, Principal Scientist II, Roche Sequencing Solutions

Jonathan is a Senior Manager at Roche, and Assay Development Lead for the AVENIO ctDNA and Tumor Tissue products.  He is a UC Berkeley and San Jose State graduate, with a MS in Molecular and Cellular Biology.  His extensive cancer research background at UC San Francisco, UC Davis, and Genentech includes researching targeted therapies, NFkB/ERK/P13K signaling pathways, and cell cycle checkpoint dysregulation. 

At Genentech, he pioneered the development of clinical NGS assays, including sequencing for cancer immunotherapy and T-cell repertoire.  Jonathan developed Genentech’s first Phase 2 clinical trial NGS assay for CMV viral biomarker sequencing.  Skilled at developing new technologies, he currently leads the development of future Roche oncology assays, such as the newly launched AVENIO Tumor Tissue CGP Kit.

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