AVENIO Millisect System

K8A2906-1843-reflection2

The AVENIO Millisect System is an automated, high-performance tissue dissection system that enables precise and consistent recovery of formalin-fixed paraffin-embedded (FFPE) tissue areas of interest for molecular pathology. The system is optimized to fit easily into a variety of clinical workflow configurations, improves diagnostic testing results by reducing false negatives, and can help you efficiently extract more clinically relevant information from every sample.

Benefits

  • Maximize clinical utility of tissue samples by identifying mutations missed with manual dissection and reducing false negative rates1,2 
  • Increase dissection efficiency and optimize results by capturing only clinically relevant cells1 
  • Improve lab workflow and minimize demands on staff by ensuring consistent sample capture through an automated, digitally assisted process3

Product Highlights

WorkflowCheveron-cropped













Digital annotation

  • Allows definition of multiple Areas of Interest (AOIs) on a single slide, without limits on geometry
  • Digitally-assisted alignment to reference slide for up to 4 serial slides
  • Intuitive software interface to guide user annotations

Automated milling

  • Faster process with fewer steps and no pre-staining
  • Precise milling displaces tissue AOIs as small as 250 µm2 using a rotating action
  • Automated consumable loading, reagent filling and unloading

Gentle recovery

  • Hands-free process minimizes potential for contamination 
  • Capillary action used to lift and recover AOIs after milling
  • No risk of burning or losing sample with gentle, non-laser optics

Comprehensive reporting

  • Electronic report file, including images, annotations and notes, exportable as a PDF 
  • Pre- and post-dissection image capture
  • Barcode scanning for improved chain of custody

Publications

Adey, N. et al. A mill based instrument and software system for dissecting slide-mounted tissue that provides digital guidance and documentation. BMC Clin Pathol. 2013; 13:29. doi:10.1186/1472-6890-13-29

Hudock, T., & Kaushal, D. A novel microdissection approach to recovering Mycobacterium tuberculosis specific transcripts from formal fixed paraffin embedded lung. J Vis Exp. 2014; 88:1-7. doi:10.3791/51693

Krizman, D., Adey, N., & Parry, R. Application of tissue mesodissection* to molecular cancer diagnostics. J Clin Pathol. 2015; 68: 166-169. doi:10.1136/jclinpath-2014-202723

Geiersbach, K. et al. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genet. 2016; 209:42-49. doi: 10.1016/j.cancergen.2015.12.004

Gustafson, H., Theiss, N., & Hnatyszyn, J.H. Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach. Integr Cancer Sci Therap. 2016; 3(4):500-503. doi:10.15761/ICST.1000197

Kader, T., et al. Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formal-fixed paraffin embedded tumor tissue. Genome Med. 2016; 8:21. doi:10.1186/s13073-016-0375-z

 

1Geiersbach K et al. Cancer Genet. 2016;209(1-2):42-49. 2.

2Gustafson H et al. Integr Cancer Sci Therap. 2016;3(4):500-503.

3Data on file.