For Expecting Parents

The Harmony Prenatal Test Analyzes DNA

During pregnancy, the mother's blood contains fragments of the developing baby’s DNA. The Harmony test analyzes this DNA in a blood sample to assess the chance for Down syndrome (trisomy 21), as well as trisomies 18 and 13, in the pregnancy.

 

A targeted approach

While traditional blood tests can miss as many as 20% of pregnancies with Down syndrome1, the Harmony test is a DNA-based technology that accurately identifies more than 99% of cases.1The Harmony Prenatal Test specifically targets the DNA in chromosomes 21, 18 and 13- the most common trisomies that occur in babies born to women of any age when no other known risk factors are known.4

Excellent quality control

The Harmony Prenatal Test incorporates extensive quality controls. These controls include measurement of the amount of the developing baby’s DNA in each sample, to ensure that there is enough DNA present to return a reliable result. While it may seem surprising, not all DNA-based genetic tests take the care to measure this important information.

Questions to ask your doctor about Harmony Prenatal Test

References

1. Norton et al. N Engl J Med. 2015 Apr 23;372(17):1589-97

2. ACOG Practice Bulletin 163. ACOG Committee on Practice Bulletins. Obstet Gynecol. 2016 May;127(5):e123-37.

3. Sparks et al. Am J Obstet Gynecol. 2012 Apr;206(4):319.e1-9.

4. Grati FR et al. Am J Med Genet Part A 152A:1434–1442.