For Expecting Parents

Using a DNA-based technology, the Harmony Prenatal Test has been shown to identify more than 99% of pregnancies with Down syndrome.1 By comparison, traditional blood tests can miss as many as 15% of pregnancies with Down syndrome.2

The Harmony test is also much less likely than traditional tests to give you a false-positive result, meaning there is much less chance your doctor would recommend follow-up invasive testing like amniocentesis.

The Harmony Prenatal Test is a screening test. Results should be confirmed with diagnostic testing such as amniocentesis. 

Read more about the accuracy of the Harmony Prenatal Test.

When you are pregnant, your blood contains pieces of DNA from your developing baby. The Harmony Prenatal Test is a test that analyzes DNA in a sample of your blood to assess the chance of Down syndrome (trisomy 21) and other chromosome conditions called trisomy 18 and trisomy 13.

Read more about the Technology behind the Harmony Prenatal Test

The Harmony test delivers clear answers as early as the first trimester with a single blood draw. Other screening tests for Down syndrome are performed later in pregnancy and require multiple office visits. Traditional 1st trimester serum screening tests are associated with a false-positive rate as high as 5%.2 
The Harmony test uses a unique method of targeted DNA analysis that, combined with extensive quality controls, achieves over 99% accuracy and a false-positive rate less than 0.1%.1

Yes, the Harmony Prenatal Test includes the option to evaluate fetal sex and the number of X and Y sex chromosomes, if you ask your doctor to request this additional analysis. 

Yes, the Harmony Prenatal Test now has the option to evaluate for the microdeletion syndrome called 22q11.2.

Yes. Recent professional society guidelines support the offering of non-invasive prenatal testing to the general population.3-4 The Harmony Prenatal Test has been extensively validated in women both over and under 35.Most babies with Down syndrome are born to women who are less than 35 years old, even though the risk of Down syndrome in a pregnancy increases with a woman’s age.5

As early as 10 weeks into your pregnancy, you can take the Harmony Prenatal Test with a simple blood draw. 

In seven days or less, your healthcare provider will receive the results and can share them with you.

 

Read more about Taking the Test

In the Resources section, you will find a list of Advocacy and Support Groups with links to organizations that support families and individuals affected by trisomies and provide information about these conditions to the public.

Yes. Harmony can be used in twin pregnancies.

Yes. In most cases, the Harmony Prenatal Test can be used in pregnancies conceived through in vitro fertilization (IVF).

For questions that relate to your specific case and personal concerns, it’s best to talk to your healthcare provider. A list of Questions for your healthcare provider you can print for your next visit is available.

References 

1. Norton et al. N Engl J Med. 2015 Apr 23;372(17):1589-97

2. ACOG Practice Bulletin 163. ACOG Committee on Practice Bulletins. Obstet Gynecol. 2007 Jan;109(1):217-27

3. Benn et al. Prenat Diagn. 2015 Aug;35(8):725-34.

4. Gregg et al. Genet Med. 2016 Oct;18(10):1056-65.

5. California Prenatal Screening Program 2009