Immunogenetics

52305_immunology_hepC

Applications

Next generation sequencing is revolutionizing immunogenetics, the branch of medical research that explores the relationship between the immune system and genetics. Many recent studies of MHC/HLA, TCR, KIR and immunoglobulins have benefited from the high throughput unambiguous data obtained using this approach, particularly from the long clonal DNA read lengths. A specific application is HLA typing, under development to someday match donors and recipients in solid organ, stem cell or bone marrow transplantations. HLA sequencing data can also be used for disease association studies as certain HLA types have been shown to be associated with diseases like rheumatoid arthritis and celiac disease. In addition, there have been studies associating particular HLA types with adverse reactions to certain drugs for example the HIV-1 drug abacavir.